Fitz Hall and Josip Skoko look likely to miss Wigan Athletic's visit to Fulham on Saturday after limping out of the thrashing of Manchester City.
Both players underwent scans on Sunday, and the results show centre-half Hall has ankle ligament damage while midfielder Skoko suffered a small tear to his hamstring.
Latics boss Paul Jewell has refused to rule either player out of his plans for Craven Cottage at this stage – but it would take a surprise recovery for them to be involved.
The more likely scenario is an absence of about three weeks,
although more will be known when they undergo a second scan.
Both players were first-half casualties against City, Skoko stretching his hamstring while defending at a corner in the 30th minute, while Hall waved the white flag at half-time following a clattering challenge from Dietmar Hamann.
Jewell told the Evening Post: "The next 48 hours are vital, we'll know a lot more about both the injuries after that.
"Hopefully they won't be out too long, and I never like ruling players out of a weekend game so early in the week.
"We'll wait and see, it is difficult putting time spans on injuries because everyone heals at a different rate.
"As for Fulham on Saturday, I don't want to make statements now which could look foolish by the time the game comes round."
The timing of Skoko's injury couldn't have been worse for the Australia international who was handed his first start of the season against City.
Jewell rewarded him for a patient approach in training and was looking forward to the 30-year-old having a run in the side.
He said: "Skoko looked confident from the first whistle on Saturday, he played a great ball for Emmerson Boyce leading up to the first goal, and then sent over the free-kick for the second.
"It's unfortunate for him. He plays for Australia, who are no mugs, and was in their World Cup squad, so he has good pedigree.
"He played well for us in the Carling Cup last season, but hasn't really had a run in the team."
Denny Landzaat and Andy Webster are likely to benefit from the expected absences.
Both came off the bench against City, Webster getting his Premiership debut following his protracted switch from Hearts.
Jewell was reasonably happy with the Scotland international's display, although admits he can play better.
He said: "Andy missed all of pre-season training and it's very difficult to catch up.
"People say you get your fitness from playing in games, but you can't just throw someone straight into a Premiership game.
"I think Andy can do better, there is a lot more to come, but he will be pleased to get his first 45 minutes in the first team and help us keep a clean sheet."
Latics still don't know when a FIFA panel will sit to fix the amount of compensation they have to pay Hearts for Webster.
The urgency for the tribunal diminished when FIFA granted the centre-half interim permission to play after his ground breaking move from Tynecastle.