WIGAN climbed into the top-three for the first time this year with a clinical display.
Dan Sarginson marked his first game at full-back with a well-taken hat-trick.
And Anthony Gelling bagged a double as Warriors – missing seven frontline players – bounced back from last week’s defeat at Leeds in emphatic style.
Delighted coach Shaun Wane said: “That was our best win of the year, even better than the Saints game. We were ruthless in attack and for our younger players, that was their coming of age.”
The emphatic win ensures the Warriors can go into Saturday’s Magic showdown with Leeds in a confident mood.
Wigan were missing seven frontline players including England World Cup internationals Sean O’Loughlin, Josh Charnley and Liam Farrell.
Australian No.1 Matty Bowen joined the list of absentees, and with his deputy Ryan Hampshire also injured, it forced a reshuffle which saw Sarginson – usually a centre – play his first match for the club at full-back.
He got the ball rolling in the seventh minute. Gelling and Jack Hughes also crossed before half-time and, with Matty Smith kicking all three conversions and a penalty, they led 20-6 at the break.
Despite the loss of Tony Clubb and Ryan Sutton to injuries, they found another gear after the break, as Joe Burgess, Sarginson (two), Dom Manfredi and Gelling crossed.
Hull FC did manage a response through Jamie Shaul and Fetuli Talanoa, adding to Gareth Ellis’ opening half try.
“Wigan pride themselves on being ruthless,” said Hull FC coach Lee Radford. “And they saw a wounded animal tonight, and pounced all over it.”