WIGAN’S injury-hit squad fell to only their second defeat in their last 13 matches as they went down 31-22 at Huddersfield.
The Warriors welcomed back Sean O’Loughlin and Matty Bowen to their depleted line-up.
And the two senior figures made an early impact, each scoring a try as the champions took a 12-0 lead early on.
But they surrendered their advantage, leaking 18 unanswered points before the break and falling further behind in the second-half.
Dom Manfredi threw them a lifeline but it wasn’t enough, with wingers Jermaine McGillvary and Joe Burgess exchanging tries before the end.
Burgess, Anthony Gelling and Jack Hughes were among the Warriors players to shine in a squad missing nine frontline stars.
Coach Shaun Wane said: “That wasn’t us. We weren’t ourselves, and fair play to Huddersfield, they wanted it a bit more.”
The result marked Wigan’s first double defeat of the year, following the Giants’ win on the opening day.
Wane reported no fresh injury concerns ahead of next week’s showdown with Castleford in a Challenge Cup quarter-final tie.