The 19-year-old five-try hero of this week's ton-up victory over Whitehaven in the Challenge Cup has not been named in the squad.
The more experienced Thomas Leuluai – who missed the massacre of the Cumbrians because he was on Test duty in Australia – resumes at scrum-half.
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Coach Brian Noble said that he was excited for Tomkins' future in the game, but defended his decision to leave him out this evening.
He said: "It's important not to get too carried away with the events of last weekend.

"We have a duty of care to the kid not to put too much pressure on him.
"His development is part of an on-going process and there are still parts of his game that he needs to work on.

"I feel excited by the potential that Sam offers, but he's very young and has got a long career stretching out ahead of him."
Noble has warned the entire Wigan team that Wolves will be offering a far greater physical challenge than Whitehaven did last time out.

He added: "We need a reality check here.
"We were aiming a few punches at our grandmother last week, but this time around there are relatives in the family who are going to be hitting us back.

"Warrington always seem capable of getting themselves up for a Wigan game and tonight will be no exception."

Wolves – who beat Wigan 32-20 at the Halliwell Jones Stadium in March – are without full back Stuart Reardon and centre Paul Johnson who were both crocked in the Challenge Cup defeat against St Helens last weekend.

But coach Paul Cullen can welcome back hooker Jon Clarke after a two match ban while Test centre Martin Gleeson is also available after injury.
Noble added: "There will still be a very impressive 13 out there facing us at all times."

Noble revealed that Warriors trained on the JJB Stadium pitch this week before it is dug up to be relaid at the weekend.

Wigan's Challenge Cup quarter-final against Leeds will be staged at Headingley on Saturday, May 31 (2.30pm) in front of the live BBC television cameras.
The Yorkshire versus Lancashire Roses cricket game on the adjacent
county ground will go ahead as normal.