Royal Bank of Scotland is set to close 259 branches - including one in the north west.
Six hundred and eighty jobs will be lost nationwide as RBS closes its 62 of its own branded branches and 197 Nat West outlets, blaming the rising number of people choosing to bank online or via mobiles instead of personally.
The bulk of the RBS closures are in Scotland - with just three in England. Little Lever, near Bolton, London Marylebone and one in Nottingham.
Pemberton and Westhoughton's Nat West branches were closed in June as part of the same programme, which will run until mid-2018.
The banking group, still 72 per cent owned by the taxpayer, is the third this week to announce branch closures and job cuts, following Lloyds and Yorkshire Building Society.
Bosses hope to limit the number of redundancies by redeploying some staff.
An RBS spokesman said: "More and more of our customers are choosing to do their everyday banking online or on mobile.
"Since 2014 the number of customers using our branches across the UK has fallen by 40 per cent and mobile transactions have increased by 73 per cent over the same period. Over five million customers now use our mobile banking app and one in five only bank with us digitally."
However the union Unite described the move as a "betrayal" and ripped into the Government for allowing the closures to proceed.
The union's national officer Rob MacGregor also said that the move could effectively signal the end of banking in branches.
He added: "The Royal Bank of Scotland has decided to decimate its bank branch network.
"Now serious questions need to be asked about whether these closures mark the end of branch network banking.
"This announcement will forever change the face of banking in this country resulting in over a thousand staff losing their jobs and hundreds of high streets without any banking facilities.
"Why is the Government signing off this alarming branch closure programme?"
RBS insisted that it is providing customers with "more ways to bank than ever before".
The move comes after the bank's chief executive Ross McEwan signalled in October that the lender was moving on from its troubled past when it posted its third consecutive quarter in the black.
Last week, the Government also said that it is dusting off plans to re-privatise the lender by offloading around two thirds of its stake, bought at the height of the financial crisis.
It plans to restart share sales in RBS by the end of the 2018-19 financial year and sell off £3 billion a year over five years.
The Government said it now faces a £26.2 billion loss on its stake in RBS, down from a previous forecast of £29.2 billion in March, after a recent recovery in the value of the bank's shares.
But it will still see the Government take a hefty loss on its stake in the lender, with shares languishing well below the average 502p-a-share price paid during the 2008 and 2009 bailout - at around 271p at today's prices.