Father of four Daniel Skelton, 33, was last seen in Scholes in the early hours of January 16.
He is described as approximately 5'7 tall, of a stocky build, light brown short hair and may have a moustache.
He is also believed to have connections in Renfrew, Paisley, Middlesbrough, Redcar, Glasgow and Liverpool.
His disappearance is being treated as high priority by the police.
A social media post said: "Daniel has left his phone, bank card, ID and all of his belongings behind.
"He has also not shown up for work. This isn't like Daniel.
"Someone must know something. Please if anyone knows anything at all, even the smallest piece of information please get in touch.
"Please Daniel get in touch and let us know you're OK."
Anyone who has seen Daniel or knows of his whereabouts should contact police on 101 and quote the report number MSP/06LL/0000182/22
Alternatively reports can also be made anonymously to the independent charity Crimestoppers on 0800 555 111.
Thanks for reading. If you value what we do and are able to support us, a digital subscription is just £1 for your first month. Try us today by clicking here