Durham skipper Paul Collingwood fell short of his twin targets on Monday morning as Lancashire secured maximum bowling points four balls before the 110-over cut-off.
Collingwood was ninth out for 97, but his hopes of a century and full batting points had already gone with his team on 375.
A spirited last-wicket stand between Irishman Barry McCarthy, who hit two sixes in his 37, and Graham Onions took Durham to 411. In seven overs to lunch Lancashire replied with eight without loss.
Resuming on 341 for six, Durham lost wickets in the day’s third and fourth overs and had added only one run.
James Weighell and Brydon Carse both edged catches when pushing forward, the former completing Tom Bailey’s well-deserved first five-wicket haul in division one.
Kyle Jarvis was the bowler when Carse gave Liam Livingstone his fourth catch at first slip.
Bailey beat Collingwood twice before he had added to his 85, while seven of McCarthy’s first 11 runs came off the edge.
The captain became the eighth batsman to fall to an edged catch when he sliced a drive off Jarvis and was well held by Karl Brown at gully.
After surviving some short stuff from Neil Wagner, who remained wicketless, McCarthy drove his sixes off Bailey, who finished with five for 110.
McCarthy lifted a catch to long-on in Simon Kerrigan’s first over of the day before Brown and Haseeb Hameed survived seven overs from Onions and Weighell.