Adrian Lam has revealed his 19-man squad to face Catalans - and a clutch of fringe-forwards are set to get a chance.
Prop Tony Clubb (knee), Gabe Hamlin (illness) and Joe Greenwood (suspension) have all dropped out of the side which beat Salford 30-22 last weekend.
Taulima Tautai (ban), Liam Farrell (pectoral) and Sam Powell (ankle) are still unavailable for selection, which looks set to providing opportunities for back-rower Liam Paisley and props Liam Byrne and Oliver Partington.
Academy forward Morgan Smithies is in the provisional squad but could drop out. And if Lam keeps with three forwards on the bench alongside Jake Shorrocks, then winger Tom Davies may also miss out. Morgan Escare has missed out and Liam Marshall (knee) was unavailable.
Catalans Dragons welcome back seasoned campaigners Greg Bird and Sam Moa. Kick-off on Sunday is 3pm.
Here are the two 19-man squads and below, Phil Wilkinson picks his likely Wigan line-up:
Wigan Warriors' 19-man squad: Joe Bullock, Joe Burgess, Liam Byrne, Tom Davies, Ben Flower, Oliver Gildart, Zak Hardaker, Willie Isa, Tommy Leuluai, Dom Manfredi, Romain Navarrete, Sean O’Loughlin, Liam Paisley, Oliver Partington, Jarrod Sammut, Dan Sarginson, Jake Shorrocks, Morgan Smithies, George Williams.
Catalans Dragons' 19-man squad: Tony Gigot, Brayden Wiliams, Lewis Tierney, Sami Langi, Matty Smith, Remi Casty, Sam Moa, Kenny Edwards, Greg Bird, Julian Bousquet, Matt Whitley, Alrix Da Costa, Mickael Goudeman, Lucas Albert, Jason Baitieri, Arthur Romano, Fouad Yaha, Sam Kasiano, Sam Tomkins.
Phil Wilkinson's predicted line-up: Hardaker; Manfredi, Sarginson, Gildart, Burgess; Williams, Sammut; Flower, Leuluai, Navarrete, Paisley, Isa, O'Loughlin. Subs: Bullock, Partington, Byrne, Shorrocks