Here are 25 pictures from times they have reigned supreme in the famous knock-out competition.
9.
1990: A group photograph of the Wigan Team after the Challenge Cup final against Warrington at Wembley Stadium in London. Wigan won the match 36-14. Photo: Credit: Bob Martin/Allsport
10.
2013 - Sean O'Loughlin of Wigan Warriors lifts the trophy after Wigan Warriors won the Tetley's Challenge Cup Final between Wigan Warriors and Hull FC at Wembley Stadium on August 24, 2013. Photo: Photo by Paul Gilham/Getty Images
11.
1992 - Wigan stand off Shaun Edwards crosses the line to score a try as wing Martin Offiah (L) celebrates during The 1992 Challenge Cup Final between Wigan and Castleford at Wembley Stadium. Photo: Photo by Stu Forster/Hulton Archive
12.
LONDON, ENGLAND - AUGUST 24: A young Wigan fan shows his support during the Tetley's Challenge Cup Final between Wigan Warriors and Hull FC at Wembley Stadium on August 24, 2013 in London, England. Photo: Photo by Julian Finney/Getty Images)