Here are 25 pictures from times they have reigned supreme in the famous knock-out competition.
17.
2013 - Wigan fans show their support during the Tetley's Challenge Cup Final between Wigan Warriors and Hull FC at Wembley Stadium. Photo: Photo by Julian Finney/Getty Images
18.
2002: Andrew Farrell of Wigan celebrates with the team and his son Owen Farrell after winning the St Helens v Wigan Warriors - Kelloggs Nutri Grain Challenge Cup Final from Murrayfield, Edinburgh. Photo: Credit: Alex Livesey/Getty Images
19.
1992: Wigan Captain Dean Bell holds the trophy aloft after the Challenge Cup final against Castleford at Wembley Stadium in London. Wigan won the match 28-12. Photo: Credit: Bob Martin/Allsport
20.
1993: A group photograph of Wigan after their victory in the Challenge Cup final at Wembley Stadium in London. Photo: Credit: Shaun Botterill/Allsport