Police at the scene of Wigan murder probe - victim named locally as mum-of-one Melissa Belshaw
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Police were called to Upholland Road to reports of an attack with a knife shortly after 4.10pm on Wednesday.
They found the woman, who is believed to be 32, had been stabbed inside a house.
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Hide AdGreater Manchester Police (GMP) described her injuries as “catastrophic”.
Despite the best efforts of paramedics she was pronounced dead at the scene.
A man in his 40s has been taken to hospital where he is in a serious condition.
It is believed he was injured trying to intervene in the stabbing, although GMP stressed that enquiries are still in their very early stages.
A 36-year-old man has been arrested on suspicion of murder and attempted murder.