Three lanes of four were blocked on the northbound M6 after a caravan overturned, say police.
Emergency services were called out to the incident at junction 31 for Preston at around 9.50am on Tuesday.
Delays were reported around the area and traffic is tailing back to junction 29 for the M65.
Police say nobody was injured in the incident and the driver declined medical help.
A spokesman for Highways England said: "Traffic Officers are on scene and have arranged recovery. Traffic passing in one lane only so please pass with care and expect delays.
"We are working as quickly as possible to reopen the lanes."
All lanes re-opened shortly after 11am.