Burnley, alongside Norwich City and Watford were relegated from the Premier League last season whilst Wigan, Rotherham United and Sunderland were all promoted from League One.
There will be plenty of bragging rights available for those in the North West this season, but staying in the division will always be the first goal for them to achieve.
Here are the latest bookies odds on who will be unable to avoid the drop.
1. Rotherham United - 6/4
After being promoted as runners-up of League One last season, at the first time of asking, the Millers are tipped as favourites to go back down.
Photo: Richard Sellers
2. Reading - 13/8
Paul Ince may have signed his son Tom, but the pair are expected to be relegated this campaign with more troublesome times ahead for the Royals.
Photo: CameraSport - Andrew Kearns
3. Birmingham City - 2/1
There were rumours Lee Bowyer could leave the Blues last season but he persists, though little is expected.
Photo: CameraSport - Dave Howarth
4. Bristol City - 3/1
It's expected to be another season of struggle for Nigel Pearson's side.
Photo: CameraSport - Rich Linley