Wigan Athletic 6 Liverpool Under-21s 1
The visitors had taken the lead with two minutes of the first half remaining through Leighton Clarkson's clinical finish.
But the half-time introduction of Kal Naismith totally changed the game in Wigan's favour.
The Scot levelled the scores within two minutes of coming on, nodding home Lee Evans' corner from close range.
And his precise corner then allowed Jolley to head Latics in front on 58 minutes.
Jolley scored his second and Wigan's third on 66 minutes, when his chasing resulted in a Liverpool defender heading the ball beyond his own goalkeeper, allowing the Latics striker to tap home from a yard.
Crankshaw - making his home debut in the unfamiliar position of right-back - made it 4-1 with a blistering strike with 11 minutes remaining.
Two minutes later, the same player won a penalty with quick feet that forced the foul from a visiting defender.
Unselfishly - on a hat-trick against his hometown side - Jolley handed the ball to substitute Joe Garner, who converted for his fourth goal in four matches played this term.
It could and should have been six in the last minutes only for Crankshaw to fire wide.
Thankfully he made amends moments later when heading home Tom Pearce's inviting cross - to bring up the half dozen!