For the last two seasons the traditional Easter fixture has not taken place due to Covid-19.
The clash is one of the highlights of the rugby league calendar, due to the intense rivalry between the sides.
They head into the game, with Wigan sitting in second, behind St Helens, in the Super League table.
Here is how the last five Good Friday meetings have ended:
5. Wigan Warriors 12-4 St Helens (2015)
Dom Manfredi and Joe Burgess both went over in a 12-4 victory in 2015. The first try came after only two minutes, while the second came in the final 10. Photo: Alex Whitehead/SWpix.com
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