Wigan Warriors' Adrian Lam provides injury update after defeat to Huddersfield Giants
Marshall suffered an injury to his left knee - the same joint he damaged last summer which cut short his season - and left the stadium on crutches, but will be assessed today.
Manfredi also left before half-time after a nasty face injury "skittled" some of his teeth.
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Hide AdCoach Adrian Lam says he may have a chance of facing Warrington on Friday.
"Dom had some teeth knocked back, skittled. It's not good," he said. "There's a chance he could play. Tony Clubb had a similar injury in the St Helens game and played the following week."
If both are ruled out, Tom Davies missed out against Huddersfield while Morgan Escare did a strong job from the bench and scored Wigan's only try.
Joe Burgess is also a week or two away from making his long-awaited return.
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Hide AdJoe Greenwood missed the Huddersfield game because of concussion protocols and is also set to return for the trip to the Halliwell Jones Stadium.
And centre Dan Sarginson had a "corked thigh" - his chances had been rated at 50-50 - and may also recover in time.